It has been described that the sensitivity of the Carba NP test may be low in the case of OXA-48-like carbapenamases and mass spectrometry based methods as well as a colorimetry based method have been described as alternatives.
Article published online: 11 October 2016
The accurate detection of carbapenemase-producing organisms is a major callenge for clinical laboratories. The Carba NP test is highly accurate but inconvenient, as it repuires fepuent preparation of fresh imipenem solution.
The detection of Carbapenemase-producing bacteria is still a challenge for many laboratories worldwide, especially in low-income countries, though critical from a clinical or epidemiological point of view.
A novel phenotypic detection strategy for class A, B and OXA-48 carbapenemases in Enterobacteriaceae using temocillin.
Comparative evaluation of Carba NP test and of ROSCO Rapid CARB Screen kit for the detection of carbapenemase-producing Enterobacteriaceae.
Evaluation of Rosco Diagnostica Rapid CARB Screen kit, for detection of carbapenemase activity.
Comparison of Rosco Neo-Sensitabs with Oxoid paper disks in EUCAST disk diffusion antimicrobial susceptibility testing on Mueller-Hinton agar
pneumoniae: improving reliability for the double carbapenemase producers
Article published online: 5 April 2013
Clin Microbiol Infect 2013; 19: E412–E415 10.1111/1469-0691.12238
Written by Miriagou et al. at the University of Athens, Greece 2013. Accepted article, Clinical Microbiology and Infection, doi:10.1111/1469-0691.12238. 09/04/2013
Evaluation of Rosco Kit (KPC/MBL Confirm Kit) for detection of class A and class B carbapenemases in Enterobacteriaceae. Written by S. Ambretti et al at University of Bologna 2013, accepted manuscript Microbial Drug Resistance doi: 10.1089/mdr.2012.0165.
EUCAST guidelines for detection of resistance mechanisms and specific resistances of clinical and/or epidemiological importance – guidelines issued December 2012 emphasizes the importance of phenotypic screening methods for infection control purposes and mentions use of ROSCO’s kits for detection of resistance mechanisms.
Nordmann P et al. Rapid detection of carbapenemase producing Enterobacteriaceae. Emerg. Infect. Dis. 18, 1503-1507, 2012.
Evaluation of ROSCO Kits for detection of ESBL, AmpC and Carbapenemases (KPC and MBL) in Enterobacteriaceae. Written by expert microbiologists from Statens Serum institute (Denmark). Karolinska University Hospital (Sweden) and University of Tromsø (Norway). Published in APMIS, 120, 724-732, 2012.
Comparison of Neo-Sensitabs (ROSCO) tablets with paper discs (OXOID) for antimicrobial susceptibility testing of Gram-negative clinical isolates according to the EUCAST recommendations; Antimicrobial susceptibility testing – EUCAST and beyond.
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